Influence of physical loading on behavioral reactions of rats in cerebral hypoperfusion

A number of clinical studies demonstrate that individual characteristics such as stress tolerance and cognitive ability can be considered not only diagnostic variables but also risk factors for severe cerebral hypoperfusion. The aim the study was to identify typological features effect physical activity on behavioral reactions rats during Material methods. Cerebral hypoperfusion modeled by bilateral carotid artery ligation. involved 280 rats, divided into equal subgroups, according sex, learning capacity. Of these, 112 animals were subjected daily short-term swimming a rehabilitation model. Before simulation, at 6, 8, 14, 21, 28, 35, 60 90 days postoperatively, tested using Morris water maze an “open field” test. Results discussion. dynamics resistance are related periodicity inflammatory, necrotic, circulatory reparative remodeling in model used. After 2-3 months study, causes stabilization indices characterizing functions below control values. decrease begins earlier from day 6 while index first decreases significantly after 3 weeks study. Factors reducing damaging effects female gender, high baseline ability. When assessing under load, with development showed recovery urgent adaptation significant increase long-term adaptation.